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Auditory cognition and communication

LUC ARNAL AND DIANE LAZARD

AUDITORY COGNITION AND COMMUNICATION

 

In both humans and animals, sound-based communication plays an essential role in the capacity to share information at a distance and to react in an appropriate and concerted manner. The loss or degradation of this essential sensory function has severe consequences for our mental health and social lives.

 Neurophysiology of auditory perception and sound-based communication

The “Auditory cognition and communication” team is interested in improving our understanding of the operations occurring within the brain to permit the processing of complex communication signals — whether verbal, non-verbal or musical — and the triggering of appropriate behavioral responses. By combining diverse methods from psychoacoustics, neuroimaging (fMRI, MEG/EEG and intracranial EEG) and neurocomputational modeling, this team contributes to the development of new theoretical and experimental frameworks for improving our understanding of the processing of these signals in the brain. The researchers compare these models in normal individuals and individuals suffering from sensory deficits (partial or profound deafness) or neurodevelopmental diseases (autism, dyslexia).

Extending these models in the context of non-verbal communication in humans and in animal models, they investigate the involvement of auditory subcortical and so-called “non-classical” limbic networks. Over and above their pertinence for fundamental research, these studies are opening up new perspectives for improving our understanding of why the cerebral responses to certain sounds are affected in diseases such as Alzheimer’s disease, mood disorders (anxiety, depression), schizophrenia or epilepsy, paving the way for new avenues of investigation into neurophysiological biomarkers for these diseases.

MEMBERS OF THE TEAM

Luc ARNAL, PhD

Luc ARNAL, PhD

Diane LAZARD MD, PHD

Diane LAZARD MD, PHD

Keith DOELLING PhD

Keith DOELLING PhD

MOST IMPORTANT PUBLICATIONS

Arnal, L.H., Kleinschmidt, A., Spinelli, L., Giraud, A.-L., and Mégevand, P. (2019). The rough sound of salience enhances aversion through neural synchronisation. Nature Communications.

Doelling, K.B., Florencia Assaneo, M., Bevilacqua, D., Pesaran, B., and Poeppel, D. (2019). An oscillator model better predicts cortical entrainment to music. Proc. Natl. Acad. Sci. U. S. A.

Rimmele, J.M., Morillon, B., Poeppel, D., and Arnal, L.H. (2018). Proactive Sensing of Periodic and Aperiodic Auditory Patterns. Trends in Cognitive Science.

Lazard, D.S., and Giraud, A.L. (2017). Faster phonological processing and right occipito-temporal coupling in deaf adults signal poor cochlear implant outcome. Nature Communications.

Arnal, L.H., Flinker, A., Kleinschmidt, A., Giraud, A.L., and Poeppel, D. (2015). Human Screams Occupy a Privileged Niche in the Communication Soundscape. Current Biology.

 

PROJECTS

Project 1: Predictive coding and role of neuronal oscillations in the processing of words and music 

The capacity of humans to process continuous sound stimuli, such as words or music, is dependent on proactive control of the oscillatory mechanisms of the auditory system. How do these neuronal mechanisms function when the perception of sounds is degraded, in the case of slight or profound hearing impairment, for example? What strategies does the human brain use in the short and long term to compensate for these sensory deficits and process such signals? The researchers of this team are addressing these fundamental and clinical questions through a series of experimental approaches in individuals with normal hearing and individuals with hearing impairment, to study:

  1. The role of neuronal oscillations in speech sampling.
  2. The role of predictive mechanisms in sound processing.
  3. The long-term cortical reorganizations involved in adaptation to a loss of auditory communication capacity. 

Project 2: The training of cerebral responses via classical and non-classical auditory circuits, in normal and pathological brains

The human auditory system is not equally sensitive to all frequencies of the audible spectrum. Certain sounds are capable of triggering stereotypical emotional responses, suggesting that, over and above individual esthetic preferences, our perception and reactions to sound are determined by factors of neurobiological origin.

In this series of experiments combining psychoacoustic and neuroimaging (fMRI, EEG, and intracranial electrophysiology) approaches, the “Auditory cognition and communication” team has recently discovered that “rough” sounds target not only the classical auditory system, but also the “non-classical” subcortical and limbic systems, with effects on the levels of stress and alertness of the listener. Surprisingly, the cerebral processing of these sounds seems to be affected in a certain number of neurodevelopmental and neurodegenerative diseases. With the aim of improving our understanding of why and how these sounds can target these circuits, the researchers are comparing the training of electrophysiological responses in the human brain (normal and pathological) and in animal models.

 

Project 3: Audiovisual interaction in hearing-impaired individuals

The exploration of audiovisual cooperation is a major axis of the research of this team. Lip-reading, despite being a major element of communication in hearing-impaired individuals, has been little explored in this population. We hypothesize that the capacity for audiovisual interaction is determined in early childhood and has little potential for improvement. An experimental paradigm will be used to test multisensory illusions in subjects with normal and impaired hearing.

The effect of learning to lip read will also be analyzed. Behavioral and neuroimaging (EEG, fMRI) analyses will be performed to identify the neuronal mechanisms involved in audiovisual integration and to improve our understanding of its interindividual variability and its consequences in cases of deafness.

PUBLICATIONS BY MEMBERS OF THE TEAM

Arnal, L.H., Kleinschmidt, A., Spinelli, L., Giraud, A.-L., and Mégevand, P. (2019). The rough sound of salience enhances aversion through neural synchronisation. Nat. Commun.

Morillon, B., Arnal, L.H., Schroeder, C.E., and Keitel, A. (2019). Prominence of delta oscillatory rhythms in the motor cortex and their relevance for auditory and speech perception. Neurosci. Biobehav. Rev.

Doelling, K.B., Florencia Assaneo, M., Bevilacqua, D., Pesaran, B., and Poeppel, D. (2019). An oscillator model better predicts cortical entrainment to music. Proc. Natl. Acad. Sci. U. S. A.

Lazard, D.S., Bergeret-Cassagne, H., Lefort, M., Leenhardt, L., Russ, G., Frouin, F., and Trésallet, C. (2018). Transcutaneous Laryngeal Ultrasonography for Laryngeal Immobility Diagnosis in Patients with Voice Disorders After Thyroid/Parathyroid Surgery. World J. Surg.

Giraud, A.L., and Arnal, L.H. (2018). Hierarchical Predictive Information Is Channeled by Asymmetric Oscillatory Activity. Neuron.

Li, T., Horta, M., Mascaro, J.S., Bijanki, K., Arnal, L.H., Adams, M., Barr, R.G., and Rilling, J.K. (2018). Explaining individual variation in paternal brain responses to infant cries. Physiol. Behav.

Rimmele, J.M., Morillon, B., Poeppel, D., and Arnal, L.H. (2018). Proactive Sensing of Periodic and Aperiodic Auditory Patterns. Trends Cogn. Sci.

Teng, X., Tian, X., Doelling, K., and Poeppel, D. (2018). Theta band oscillations reflect more than entrainment: behavioral and neural evidence demonstrates an active chunking process. Eur. J. Neurosci.

Anderson, C.A., Lazard, D.S., and Hartley, D.E.H. (2017). Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing. Hear. Res.

Marozeau, J., Ardoint, M., Gnansia, D., and Lazard, D.S. (2017). Acoustic match to electric pulse trains in single-sided deafness cochlear implant recipients. In International Symposium on Auditory and Audiological Research, p.

Bergeret-Cassagne, H., Lazard, D.S., Lefort, M., Hachi, S., Leenhardt, L., Menegaux, F., Russ, G., Trésallet, C., and Frouin, F. (2017). Sonographic Dynamic Description of the Laryngeal Tract: Definition of Quantitative Measures to Characterize Vocal Fold Motion and Estimation of Their Normal Values. J. Ultrasound Med.

Lazard, D.S., and Giraud, A.L. (2017). Faster phonological processing and right occipito-temporal coupling in deaf adults signal poor cochlear implant outcome. Nat. Commun.

Arnal, L.H., and Kleinschmidt, A.K. (2017). Entrained delta oscillations reflect the subjective tracking of time. Commun. Integr. Biol.

Pefkou, M., Arnal, L.H., Fontolan, L., and Giraud, A.L. (2017). θ-band and β-band neural activity reflects independent syllable tracking and comprehension of time-compressed speech. J. Neurosci.

Arnal, L.H. (2016). Le cri humain: Une niche acoustique particulière. Medecine/Sciences.

Arnal, L.H., Poeppel, D., and Giraud, A.-L. (2016). A Neurophysiological Perspective on Speech Processing in “The Neurobiology of Language.” In Neurobiology of Language, p.

Morillon, B., Schroeder, C.E., Wyart, V., and Arnal, L.H. (2016). Temporal prediction in lieu of periodic stimulation. J. Neurosci.

Cohen, M.-E., Lefort, M., Bergeret-Cassagne, H., Hachi, S., Li, A., Russ, G., Lazard, D., Menegaux, F., Leenhardt, L., Trésallet, C., et al. (2015). Quantification of vocal fold motion using echography: application to recurrent nerve paralysis detection. In Medical Imaging 2015: Computer-Aided Diagnosis, p.

Blamey, P.J., Maat, B., Başkent, D., Mawman, D., Burke, E., Dillier, N., Beynon, A., Kleine-Punte, A., Govaerts, P.J., Skarzynski, P.H., et al. (2015). A retrospective multicenter study comparing speech perception outcomes for bilateral implantation and bimodal rehabilitation. Ear Hear.

Song, J.J., Vanneste, S., Lazard, D.S., Van de Heyning, P., Park, J.H., Oh, S.H., and De Ridder, D. (2015). The role of the salience network in processing lexical and nonlexical stimuli in cochlear implant users: An ALE Meta-Analysis of PET Studies. Hum. Brain Mapp.

Arnal, L.H., Doelling, K.B., and Poeppel, D. (2015). Delta-beta coupled oscillations underlie temporal prediction accuracy. Cereb. Cortex.

Arnal, L.H., Poeppel, D., and Giraud, A.L. (2015). Temporal coding in the auditory cortex. In Handbook of Clinical Neurology.

Arnal, L.H., Flinker, A., Kleinschmidt, A., Giraud, A.L., and Poeppel, D. (2015). Human Screams Occupy a Privileged Niche in the Communication Soundscape. Curr. Biol.

Doelling, K.B., and Poeppel, D. (2015). Cortical entrainment to music and its modulation by expertise. Proc. Natl. Acad. Sci. U. S. A.

Gnansia, D., Lazard, D.S., Léger, A.C., Fugain, C., Lancelin, D., Meyer, B., and Lorenzi, C. (2014). Role of slow temporal modulations in speech identification for cochlear implant users. Int. J. Audiol.

Lazard, D.S., Innes-Brown, H., and Barone, P. (2014). Adaptation of the communicative brain to post-lingual deafness. Evidence from functional imaging. Hear. Res.

Doelling, K.B., Arnal, L.H., Ghitza, O., and Poeppel, D. (2014). Acoustic landmarks drive delta-theta oscillations to enable speech comprehension by facilitating perceptual parsing. Neuroimage.

Lazard, D.S., Lee, H.J., Truy, E., and Giraud, A.L. (2013). Bilateral reorganization of posterior temporal cortices in post-lingual deafness and its relation to cochlear implant outcome. Hum. Brain Mapp.

Lazard, D.S., Giraud, A.-L., and Barone, P. (2013). Multisensory Interactions in Auditory Cortex and Auditory Rehabilitation in Deafness.

Lazard, D.S., Collette, J.L., and Perrot, X. (2012). Speech processing: From peripheral to hemispheric asymmetry of the auditory system. Laryngoscope.

Verhaert, N., Lazard, D.S., Gnansia, D., Bbar, J.P., Romanet, P., Meyer, B., Pan, V., Mollard, D., and Truy, E. (2012). Speech performance and sound localization abilities in neurelec digisonic® SP binaural cochlear implant users. Audiol. Neurotol.

Lazard, D.S., Marozeau, J., and McDermott, H.J. (2012). The sound sensation of Apical electric stimulation in cochlear implant recipients with contralateral residual hearing. PLoS One.

Blamey, P., Artieres, F., Başkent, D., Bergeron, F., Beynon, A., Burke, E., Dillier, N., Dowell, R., Fraysse, B., Gallégo, S., et al. (2012). Factors affecting auditory performance of postlinguistically deaf adults using cochlear implants: An update with 2251 patients. Audiol. Neurotol.

Lazard, D.S., Godiris-Petit, G., Wagner, I., Sarfati, E., and Chabolle, F. (2012). Early detection of hypocalcemia after total/completion thyroidectomy: Routinely usable algorithm based on serum calcium level. World J. Surg.

Lazard, D.S., Vincent, C., Venail, F., van de Heyning, P., Truy, E., Sterkers, O., Skarzynski, P.H., Skarzynski, H., Schauwers, K., O’Leary, S., et al. (2012). Pre-, Per- and Postoperative Factors Affecting Performance of Postlinguistically Deaf Adults Using Cochlear Implants: A New Conceptual Model over Time. PLoS One.

Arnal, L.H. (2012). Predicting “when” using the motor system’s beta-band oscillations. Front. Hum. Neurosci.

Morillon, B., Liégeois-Chauvel, C., Arnal, L.H., Bénar, C.G., and Giraud, A.L. (2012). Asymmetric function of theta and gamma activity in syllable processing: An intra-cortical study. Front. Psychol.

Arnal, L.H., and Giraud, A.L. (2012). Cortical oscillations and sensory predictions. Trends Cogn. Sci.

Giraud, A.L., Lazard, D., and Lee, H.J. (2011). Cochlear implant outcome and functional brain organization in deaf subjects. Semin. Hear.

Lazard, D.S., Tosello, M., Bozorg-Grayeli, A., Vitte, E., Bouccara, D., Kalamarides, M., and Sterkers, O. (2011). Early complications and symptoms of cerebellopontine angle tumor surgery: A prospective analysis. Eur. Arch. Oto-Rhino-Laryngology.

Arnal, L.H., Wyart, V., and Giraud, A.L. (2011). Transitions in neural oscillations reflect prediction errors generated in audiovisual speech. Nat. Neurosci.

Lazard, D.S., Bordure, P., Lina-Granade, G., Magnan, J., Meller, R., Meyer, B., Radafy, E., Roux, P.E., Gnansia, D., Péan, V., et al. (2010). Speech perception performance for 100 post-lingually deaf adults fitted with Neurelec cochlear implants: Comparison between Digisonic® Convex and Digisonic® SP devices after a 1-year follow-up. Acta Otolaryngol.

Lazard, D.S., Blumen, M., Lévy, P., Chauvin, P., Fragny, D., Buchet, I., and Chabolle, F. (2009). The tongue-retaining device: Efficacy and side effects in obstructive sleep apnea syndrome. J. Clin. Sleep Med.

Arnal, L.H., Morillon, B., Kell, C.A., and Giraud, A.L. (2009). Dual neural routing of visual facilitation in speech processing. J. Neurosci.